School of Health Science

Dr. Shubham Dwivedi, Assistant Professor

Dr. Shubham Dwivedi

Assistant Professor –Department of Pharmaceutical Science, School of Health Sciences

Area of Interest:

Neurological disorders, Nerve-Cancer interaction, Autism, Pharmacological screening and Preclinical model development

PhD., Pharmacy (Pharmacology), Birla Institute of Technology and Science (BITS)-Pilani Hyderabad Campus, India, 2020

MS (Pharm.), Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, India, 2014

B. Pharm., Rajiv Gandhi Technical University, Bhopal, India, 2012

Career Graph:

  • Assistant Professor, School of Health Sciences
  • Postdoctoral Fellow, University of Saskatchewan, Canada, March 2020–July 2021
  • More than 7 years of research experience

Papers published in journals: 12

Papers presented in conferences: 13

Citations: 403

h-index: 8, i10-index: 8

Research:

Contribution:

  • Pre-clinical model development for autism spectrum disorder
  • Exploration of in vitro models for perineural invasion
  • Knowledge addition to the public domain by publishing several (12) peer-reviewed international articles.

Recent Publications:

Papers published in journals (Peer reviewed)

  • Dwivedi, S., Bautista, M., Shrestha, S., Elhasasna, H., Chaphekar, T., Vizeacoumar, F. S., & Krishnan, A. (2021). Sympathetic signaling facilitates progression of neuroendocrine prostate cancer. Cell death discovery, 7(1), 1-8
  • Krishnan, A., Dwivedi, S., Chandrasekhar, A., Areti, A., & Zochodne, D. W. (2021). In vitro priming response in dorsal root ganglia partially mimics injury-driven pre-conditioning response and reprograms neurons for enhanced outgrowth. Molecular and Cellular Neuroscience, 110, 103573
  • Dwivedi, S., & Krishnan, A. (2020). Neural invasion: a scenic trail for the nervous tumor and hidden therapeutic opportunity. American Journal of Cancer Research, 10(8), 2258
  • Dwivedi, S., Medishetti, R., Rani, R., Sevilimedu, A., Kulkarni, P., & Yogeeswari, P. (2019). Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism. Journal of pharmacological and toxicological methods, 95, 56-65
  • Kasturi, S. P., Surarapu, S., Uppalanchi, S., Dwivedi, S., Yogeeswari, P., Sigalapalli, D. K., ... & Anireddy, J. S. (2018). Synthesis, molecular modeling and evaluation of α-glucosidase inhibition activity of 3, 4-dihydroxy piperidines. European journal of medicinal chemistry, 150, 39-52
  • Kasturi, S., Surarapu, S., Uppalanchi, S., Anantaraju, H. S., Dwivedi, S., Yogeeswari, P., ... & Anireddy, J. S. (2018). Synthesis of New Heteroaryl Substituted Morpholine Tagged Triazines and Evaluation of their Cytotoxic Activity. Letters in Drug Design & Discovery, 15(2), 181-192
  • Kasturi, S., Surarapu, S., Uppalanchi, S., Anireddy, J. S., Dwivedi, S., Anantaraju, H. S., ... & Ethiraj, K. S. (2017). Synthesis and α-glucosidase inhibition activity of dihydroxy pyrrolidines. Bioorganic & medicinal chemistry letters, 27(12), 2818-2823
  • Kasturi, S., Surarapu, S., Bathoju, C. C., Uppalanchi, S., Dwivedi, S., Perumal, Y., ... & Anireddy, J. S. (2017). Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors. MedChemComm, 8(8), 1618-1630
  • Jangra, A., Sriram, C. S., Dwivedi, S., Gurjar, S. S., Hussain, M. I., Borah, P., &  Lahkar, M. (2017). Sodium phenylbutyrate and edaravone abrogate chronic restraint stress-induced behavioral deficits: implication of oxido-nitrosative, endoplasmic reticulum stress cascade, and neuroinflammation. Cellular and molecular neurobiology, 37(1), 65-81
  • Sulakhiya, K., Keshavlal, G. P., Bezbaruah, B. B., Dwivedi, S., Gurjar, S. S., Munde, N., ... & Gogoi, R. (2016). Lipopolysaccharide induced anxiety-and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin. Neuroscience letters, 611, 106-111
  • Jangra, A., Dwivedi, S., Sriram, C. S., Gurjar, S. S., Kwatra, M., Sulakhiya, K., ... & Lahkar, M. (2016). Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice. European Journal of Pharmacology, 770, 25-32
  • Jangra, A., Kasbe, P., Pandey, S. N., Dwivedi, S., Gurjar, S. S., Kwatra, M., ... & Lahkar, M. (2015). Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus. Biological trace element research, 168(2), 462-471
  • Sulakhiya, K., Kumar, P., Jangra, A., Dwivedi, S., Hazarika, N. K., Baruah, C. C., & Lahkar, M. (2014). Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. European journal of pharmacology, 744, 124-131

Selected conference papers:

  • Dwivedi, S., Bautista, M., Shrestha, S., Hall, J., Krishnan, A., (2021, August) Neuroinflammation facilitates chemotherapy induced neuropathic pain, CAN-CAN meeting 2021
  • Krishnan, A., Dwivedi, S., Bautista, M., Iftikhar, T., Adrenergic signaling induces neuroendocrine differentiation of prostate adenocarcinoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81
  • Dwivedi, S., Bautista, M. and Krishnan, A., (2021, January). Development and characterization of in vitro perineural invasion model to study peripheral nerve-cancer cell interaction. SfN Global Connectome: A Virtual Event
  • Dwivedi, S., and Perumal, Y., (2019, July). VPA treatment in neurosphere culture: an approach towards in vitro modelling of autism. International Society of Neurochemistry (ISN) and American Society of Neurochemistry (ASN) Meeting 2019, Montreal, Canada. In JOURNAL OF NEUROCHEMISTRY (Vol. 150, pp. 106-106). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY
  • Dwivedi, S., Medishetty, R., Kulkarni, P., & Perumal, Y. (2017, August). Zebrafish larvae model: a novel approach to study autism. International Society of Neurochemistry (ISN) and European Society of Neurochemistry (ESN) Meeting 2017, Paris, France. In JOURNAL OF NEUROCHEMISTRY (Vol. 142, pp. 198-198). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY

Professional Memberships/Fellowship:

  • Lifetime member of Indian Academy of Neuroscience (IAN)
  • Member of International Society for Neurochemistry (ISN)
  • Member of Asian-Pacific Society for Neurochemistry (APSN)
  • Member of Society for Neuroscience (SfN)
  • Lifetime member of Society of Pharmaceutical Education & Research (SPER)
  • Awarded Senior Research Fellowship (SRF) from Indian Council of Medical Research (ICMR), India (2018)

Honours and Achievements:

International Awards:

  • Recipient of a 2020 Trainee Professional Development Award from the Society for Neuroscience
  • Travel award from International Society for Neurochemistry (ISN) for poster presentation at ISN-ASN Meeting, 2019, Montreal, Canada
  • Travel award from ISN for poster presentation at ISN-APSN Meeting, Neuroscience School cum conference, 2018, Macau, China
  • Travel award from Department of Science and Technology (DST)-Science and Engineering Research Board (SERB), Government of India, for poster presentation at ISN- ESN meeting, 2017, Paris, France
  • Selected for fully funded 2nd IBRO/APRC Chandigarh Neuroscience School (2016), Chandigarh, India and won 3rd prize for oral presentation

National Awards:

  • Travel award from The Wellcome Trust DBT India Alliance for attending The Wellcome Trust DBT India Alliance Science Communication Workshop 2018, New Delhi, India

Personal interests

  • Singing
  • Writing
  • Cricket
  • Chess
  • Motivational Speaker